Sickle Cell Anaemia Profile

In sickle cell anemia, there is a presence of a type of hemoglobin called hemoglobin S (HbS). HbS causes cells to form into a curved, sickle shape. Thus, due to this shape the cells may clog the blood vessels and thus the organs of the body do not get the required oxygen they need.

Below tests are performed for its diagnosis:

Complete blood count – CBC indicates the number of red blood cells present and how much hemoglobin is in them and will evaluate the size and shape of the RBCs present.

Blood smear – Through this test the number and type of red blood cells are evaluated to see if they are normal. Sickle-shaped RBCs may be seen on the blood smear.

Hemoglobin S solubility test and sodium metabisulfite test – This test is used to screen for the presence of hemoglobin S.

Hemoglobinopathy (Hb) evaluation – Here the different types of hemoglobin are separated to identify and quantify. Methods adopted for it are Hemoglobin electrophoresis and Hemoglobin fractionation by HPLC.