Tumor Markers (Screening, Diagnostic)

In cancer, tumor markers are produced by cancerous cells or other cells. These markers are normally produced in the body but their production levels increase in case of cancer.
These markers are used in identifying, diagnosing and managing cancer. However, for confirming the diagnosis tumor marker tests are combined with other tests.

Used for:

  • Planning the appropriate therapy
  • Identifying the stage of the disease and/or the patient’s prognosis
  • Checking whether cancer is responding to treatment or not
  • Checking for recurrence of disease

Tumor markers in Males:

Prostate Specific Antigen

  • For Prostate cancer
  • To help in diagnosis, assess response to treatment and look for recurrence

Alpha Feto Protein

  • For Liver cancer and Germ cell tumors
  • To help diagnose liver cancer and follow response to treatment; to assess stage, prognosis, and response to treatment of germ cell tumors

Beta- HCG

  • For Choriocarcinoma and germ cell tumors
  • To assess stage, prognosis and response to treatment

CA- 19.9

  • For Pancreatic cancer, gallbladder cancer, bile duct cancer, and gastric cancer
  • To assess whether treatment is working

CEA:

  • CEA levels may also be raised in Colon carcinoma, gastric carcinoma, pancreatic carcinoma, lung carcinoma, breast carcinoma, and medullary thyroid carcinoma, as well as some non-neoplastic conditions like ulcerative colitis, pancreatitis, cirrhosis, COPD, Crohn’s disease, hypothyroidism as well as in smokers.

Tumour markers for Females:

CA-125

  • For Ovarian cancer
  • To help in diagnosis, assessment of response to treatment, and evaluation of recurrence

Alpha feto protein

  • For Liver cancer and germ cell tumors
  • To help diagnose liver cancer and follow response to treatment; to assess stage, prognosis, and response to treatment of germ cell tumors

Beta- HCG

  • For Choriocarcinoma and germ cell tumors
  • To assess stage, prognosis, and response to treatment

CA- 19.9

  • For Pancreatic cancer, gallbladder cancer, bile duct cancer, and gastric cancer
  • To assess whether treatment is working

CA-15.3

  • For Breast cancer
  • To assess whether treatment is working or disease has recurred

CEA

  • CEA levels may also be raised in Colon carcinoma, gastric carcinoma, pancreatic carcinoma, lung carcinoma, breast carcinoma, and medullary thyroid carcinoma, as well as some non-neoplastic conditions like ulcerative colitis, pancreatitis, cirrhosis, COPD, Crohn’s disease, hypothyroidism as well as in smokers.
    https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet